Increasing growth hormone and IGF-1 levels may carry potential risks, including worsening insulin resistance in some individuals and, theoretically, stimulating the growth of existing cancers
Because retatrutide is not yet licensed in the UK, there is currently no officially approved prescribing information, patient information leaflet, or MHRA-approved dosing schedule
The prescribing information does not list BMI, obesity, or overweight as criteria for use
Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis
For people focused on longevity, HRV is appealing because it is non-invasive, measurable at home, and trackable daily
Modifications to the peptide chain to reduce degradation by DPP-4, combined with acylation to promote non-covalent binding to albumin, resulted in long-acting formulations, enabling their use in clinical practice.3,5 Initially, GLP-1 receptor monoagonists were marketed with the aim of treating type 2 diabetes, harnessing their incretin effect and glucose-dependent mechanism, along with their capacity to reduce body weight and their beneficial effects on associated comorbidities.1,3,5 Subsequently, research shifted its focus to obesity, employing higher doses than those used for diabetes.3,5 This was followed by the development of unimolecular structures with multi-receptor activity, such as GIP/GLP-1 and GLP-1/glucagon (GCG) coagonists, as well as GIP/GLP-1/GCG triagonists