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10.1016/j.cmet.2020.03.004 54 KwonD

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The reliance of tumor metabolism on amino acids, especially amino acid transport systems, has been extensively studied over the past decade

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It was reported to possess antioxidative properties and act as an anti-inflammatory agent in cases of liver injury due to iron overload ( 3.3.3 Fructus Lycii and Salvia mTCNiltiorrhiza bunge extract Fructus Lycii (Gouqizi) and Salvia miltiorrhiza Bunge (Danshen) are commonly utilized in TCM for addressing deficiencies, improving blood circulation, or as daily nutritional supplements ( Furthermore, another investigation revealed that Qi-Shen-Tang, a TCM formula containing Gouqizi and Danshen in a 1:1 ratio, can suppress ferroptotic characteristics of the retina in mice with RP by blocking the NFE2L2/GPX4 signaling pathway ( 3.3.4 Astragaloside-IV Decoctions made from the roots of Astragalus membranaceus, commonly referred to as Huangqi, have been extensively utilized in TCM to address viral and bacterial infections as well as inflammation ( 3.4 Inhibitors of ferroptosis-related proteins 3.4.1 Lipoxygenase inhibitor Lipoxygenases (LOXs) are enzymes that metabolize arachidonic acid and polyunsaturated fatty acids, leading to lipid peroxidation and ferroptosis induction ( 3.4.2 Zinc protoporphyrin IX HMOX1 plays a crucial role in controlling atRAL-induced ferroptosis in photoreceptors and the RPE ( 3.4.3 BMS309403 BMS-309403 (C31H26N2O3) demonstrates strong inhibitory effects on adipocyte fatty acid binding protein (FABP) and is orally active and selective