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Phenotype of sarcopenic obesity in older individuals with a history of falling
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This review summarizes the current research findings by which GLP-1RAs treatment of diabetic osteoporosis, postmenopausal osteoporosis and glucocorticoid-induced osteoporosis and describes possible mechanisms, such as GLP-1R/MAPK signaling pathway, GLP-1R/PI3K/AKT signaling pathway and Wnt/-catenin pathway, that are associated with GLP-1RAs and osteoporosis
Exendin-4 (exenatide), for example, shows greater beta-arrestin recruitment relative to cAMP signaling compared to native GLP-1, while semaglutide shows relatively balanced signaling
And for those curious about whether refrigeration is strictly necessary, this article covers the specifics
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