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doi: 10.1001/jama.2019.2942 25 ChristakoudiSTsilidisKKEvangelouERiboliE

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However, it is consistent with other studies, so it warrants further study to better understand the biological mechanisms. Public health implications The researchers acknowledged study limitations, including the potential for confounding in observational studies and the fact that several cancer types in the analysis had low event rates, leading to wide confidence intervals and limiting statistical power

Recent mechanistic work has mapped biased agonism and receptor compartmentalisation relevant to long-acting analogues such as semaglutide [17][18][19]

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GLP-1 medications are highly effective at reducing caloric intake, but they do not replace the physiologic benefits of exercise, he says