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For individuals considering GLP-1 treatment, the most appropriate next step is a doctor-led consultation rather than self-selecting a specific medication

These results suggested that GLP-1 expression was gradually decreased in CM, and also revealed that although the protein expression of GLP-1R was upregulated after NTG stimulation, the amount of GLP-1Rs that can be activated was decreased, so the activity of GLP-1R in the TNC in CM model was actually inhibited

doi:10.1007/s00125-009-1499-0

What matters is the average temperature and the extremes

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