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Lastly, a challenge in the field stemming from the clinically silent nature of PanINs and PanIN progression is the absence of a surrogate marker for pre-malignant progression
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The OR for achieving a weight loss of at least 5% with tirzepatide 5 mg, 10 mg and 15 mg (vs GLP-1 RAs) was, respectively, 1.96 (95% CI 1.01, 3.80 [ I 2 61%]), 4.79 (95% CI 1.95, 11.73 [ I 2 74%]) and 4.57 (95% CI 3.38, 6.18 [ I 2 0%]) (ESM Table 2)
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Tirzepatide produces similar or better figures
