When GLP-1 levels are low, the finely tuned communication along the gut-brain axis becomes disrupted
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In the brain, they observed changes in the expression of genes associated with mitochondrial and neuronal structure, mitochondrial respiration, and neurodevelopmental processes, with key genes (e.g., fkbp5 and ucp2 ) correlating with the response to SSRIs and neurodevelopment
Hipoglucemia: Aunque los GLP-1 tienen bajo riesgo de hipoglucemia cuando se usan solos, el riesgo aumenta cuando se combinan con insulina o sulfonilureas