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Front Cell Dev Biol (2021) 9:722412
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Particularly in tumor cells with active glycolysis, accumulated lactate stabilizes and increases the activity of proglycolytic transcription factors such as HIF-1 and c-Myc, as well as the expression of their downstream target genes, via lactylation, thereby forming a self-reinforcing positive feedback loop that further entrenches the glycolytic phenotype of tumors [78, 79]
10.1016/j.diabres.2015.10.014 71 ShahbaziM.QudsiyaZ.FahelA.AminiA.TanoliT
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