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10.1001/jamanetworkopen.2024.57349 JAMA Netw Open

First discovered in human plasma in the early 1970s, this molecule has since gained attention for its regulatory role in numerous biological pathways related to repair, regeneration, and protection

And I think all of those are an issue

The reaction between those enzymes and 3,4-dihydroxyphenylacetic acid, which displays a carboxylic group in its side chain (like L -DOPA), was associated with lower K m values when an arginine was present at this position ( To PPO-6) rather than an isoleucine ( To PPO-2) 52

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Before we dive into the how-to, let's touch on the why