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Clinical trials have demonstrated substantial efficacy, with patients achieving A1c reductions of 1.9% to 2.4% in type 2 diabetes and weight loss averaging 15% to 21% of baseline body weight after 72 weeks in adults without diabetes (more modest in those with type 2 diabetes)
Biometals 27 , 349361 (2014)
GHK-Cu also stimulates both collagen synthesis and matrix metalloproteinases that break collagen down, so unbalanced or excessive use could in principle disrupt extracellular-matrix homeostasis
This multicenter, randomized controlled trial evaluated the maternal and fetal outcomes of screening and initiating treatment for gestational diabetes before 20 weeks gestation
Schratzberger, P
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