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Human data is limited, and it should only be used under medical supervision

Using Tretinoin with Moisturizer Clinical findings on Tretinoin usage reveal that patients could experience initial dryness and irritation, especially in the first few weeks of use until their skin starts to adapt to the new medication

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Skin aging and oxidative stress

Cyanocobalamin or methylcobalamin (B12): Occasionally causes injection site discomfort and redness